Oral acanthosis nigricans, tripe palms and sign of leser-trélat in a patient with gastric adenocarcinoma

Int J Dermatol. 2004 Jul;43(7):530-2. doi: 10.1111/j.1365-4632.2004.02159.x.


Acanthosis nigricans (AN), tripe palms (TP) and the sign of Leser-Trélat (LT) may be seen with the presence of malignancy. Acanthosis nigricans may have a mucocutaneous localization involving the oral mucosa with papillomatous and verrucous lesions usually on the lips and buccal mucosa. These paraneoplastic dermatoses are generally linked with intra-abdominal malignancy, most often gastric adenocarcinoma. Improvement of the associated dermatoses after the treatment of the malignancy has been frequently observed. We report the case of a 53-year-old man suffering from advanced gastric adenocarcinoma, in which metastases seemed to sustain all three paraneoplastic dermatoses. To the best of our knowledge this is the first case of a patient showing manifestations of all three paraneoplastic dermatoses. Patients presenting with this set of dermatoses should be suspected to harbor an occult malignancy, or have persistence of a known malignancy.

Publication types

  • Case Reports

MeSH terms

  • Acanthosis Nigricans / etiology*
  • Adenocarcinoma / complications*
  • Adenocarcinoma / therapy
  • Antineoplastic Agents / therapeutic use
  • Fatal Outcome
  • Gastrectomy
  • Humans
  • Keratosis, Seborrheic / etiology*
  • Male
  • Middle Aged
  • Mouth Diseases / etiology
  • Paraneoplastic Syndromes / etiology*
  • Stomach Neoplasms / complications*
  • Stomach Neoplasms / therapy


  • Antineoplastic Agents