A new modality for immunosuppression: targeting the JAK/STAT pathway

Nat Rev Drug Discov. 2004 Jul;3(7):555-64. doi: 10.1038/nrd1441.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Immunosuppression / methods*
  • Immunosuppressive Agents / chemistry
  • Immunosuppressive Agents / pharmacology*
  • Interleukin Receptor Common gamma Subunit
  • Janus Kinase 3
  • Molecular Structure
  • Mutation
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Protein-Tyrosine Kinases / genetics
  • Receptors, Interleukin-7 / genetics
  • Receptors, Interleukin-7 / immunology*
  • Severe Combined Immunodeficiency / drug therapy
  • Severe Combined Immunodeficiency / enzymology
  • Signal Transduction / drug effects*
  • Signal Transduction / immunology
  • Trans-Activators / antagonists & inhibitors*

Substances

  • Enzyme Inhibitors
  • IL2RG protein, human
  • Immunosuppressive Agents
  • Interleukin Receptor Common gamma Subunit
  • Receptors, Interleukin-7
  • Trans-Activators
  • Protein-Tyrosine Kinases
  • JAK3 protein, human
  • Janus Kinase 3