Comparison of antioxidants in the ability to prevent cataract in prematurely aging OXYS rats

Bull Exp Biol Med. 2004 Mar;137(3):249-51. doi: 10.1023/b:bebm.0000031561.71977.85.


The biological model of prematurely aging OXYS rats is proposed for evaluation of anticataract activity of preparations. Pathological changes in the lens develop in 2-month-old OXYS rats. By the 6th month of life cataract morbidity rate attains 100%. Adrusen Zinco, Mirtilene Forte, blueberry extract, and vitamin E (Russian and from Sigma) possessing antioxidant properties and given with food decreased the number of OXYS rats with cataract. The preparation from blueberry Mirtilene Forte and blueberry extract normalized the content of lipid peroxidation products in the blood. Blueberry extract manufactured in Russia decreased the index of lipid atherogenicity that was high in OXYS rats.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging, Premature / complications*
  • Animals
  • Antioxidants / pharmacology*
  • Blueberry Plants
  • Cataract / etiology
  • Cataract / metabolism
  • Cataract / pathology
  • Cataract / prevention & control*
  • Lipid Peroxidation / drug effects
  • Male
  • Plant Extracts / pharmacology
  • Rats
  • Rats, Wistar
  • Vitamin E / pharmacology


  • Antioxidants
  • Plant Extracts
  • Vitamin E