DNA vaccines against human immunodeficiency virus type 1

Immunol Rev. 2004 Jun:199:144-55. doi: 10.1111/j.0105-2896.2004.00151.x.


Development of a vaccine against human immunodeficiency virus type 1 (HIV-1) is the main hope for controlling the acquired immunodeficiency syndrome pandemic. An ideal HIV vaccine should induce neutralizing antibodies, CD4+ helper T cells, and CD8+ cytotoxic T cells. While the induction of broadly neutralizing antibodies remains a highly challenging goal, there are a number of technologies capable of inducing potent cell-mediated responses in animal models, which are now starting to be tested in humans. Naked DNA immunization is one of them. This review focuses on the stimulation of HIV-specific T cells and discusses in the context of the current 'state-of-art' of DNA vaccines, the areas where this technology might assist either alone or as a part of more complex vaccine formulations in the HIV vaccine development.

Publication types

  • Review

MeSH terms

  • AIDS Vaccines / genetics*
  • AIDS Vaccines / immunology*
  • Acquired Immunodeficiency Syndrome / prevention & control
  • Antigen Presentation / immunology
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • CpG Islands / genetics
  • CpG Islands / immunology
  • HIV-1 / immunology*
  • Humans
  • Plasmids / genetics
  • Plasmids / immunology
  • Vaccines, DNA / genetics*
  • Vaccines, DNA / immunology*


  • AIDS Vaccines
  • Vaccines, DNA