Age-related changes in ocular and corneal aberrations

Am J Ophthalmol. 2004 Jul;138(1):143-6. doi: 10.1016/j.ajo.2004.01.051.


Purpose: To compare the ocular and corneal higher-order aberrations (HA) in eyes of different ages.

Design: Observational cross-sectional study.

Methods: Sixty-six eyes of 66 normal subjects (age range 4-69 years; average 37.4 +/- 15.4 years) were examined. Wavefront aberrations of the whole eye (ocular) and cornea were measured for the central 4 mm using a Hartmann-Shack aberrometer.

Results: Ocular Coma-like aberration (r = 0.270, P =.029), Spherical-like aberration (r = 0.531, P =.001), and total HA(r = 0.431, P =.001) were significantly correlated with age, whereas the corneal aberrations were not significantly correlated. The ocular total HA aberrations increased significantly after age 50 years.

Conclusions: After 50 years of age, ocular aberrations increased abruptly due to the increase of lenticular HA. Customized ablation should be carefully considered, especially in eyes of presbyopic age.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aging / physiology*
  • Child
  • Child, Preschool
  • Corneal Diseases / physiopathology*
  • Cross-Sectional Studies
  • Diagnostic Techniques, Ophthalmological
  • Humans
  • Middle Aged
  • Refractive Errors / physiopathology*
  • Vision Disorders / physiopathology*