Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity

Nat Med. 2004 Aug;10(8):813-5. doi: 10.1038/nm1078. Epub 2004 Jul 4.


There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Corneal Transplantation / immunology*
  • Dendritic Cells / immunology
  • Flow Cytometry
  • Gene Expression Regulation / immunology*
  • Glycoproteins
  • Graft Rejection / immunology
  • Humans
  • Hypersensitivity, Delayed / immunology*
  • Keratitis / immunology*
  • Lymphangiogenesis / immunology*
  • Membrane Transport Proteins
  • Mice
  • Microscopy, Fluorescence
  • Models, Animal
  • Signal Transduction / immunology*
  • Vascular Endothelial Growth Factor C / metabolism
  • Vascular Endothelial Growth Factor Receptor-3 / antagonists & inhibitors*
  • Vascular Endothelial Growth Factor Receptor-3 / metabolism
  • Vesicular Transport Proteins


  • Glycoproteins
  • LYVE1 protein, human
  • Membrane Transport Proteins
  • Vascular Endothelial Growth Factor C
  • Vesicular Transport Proteins
  • Xlkd1 protein, mouse
  • Vascular Endothelial Growth Factor Receptor-3