Gonadotropin treatment of an azoospermic patient with a Y-chromosome microdeletion

Fertil Steril. 2004 Jul;82(1):218-9. doi: 10.1016/j.fertnstert.2003.11.055.


Objective: To report on the treatment with recombinant FSH of an azoospermic normogonadotropic patient with a Y-chromosome microdeletion.

Design: Case report.

Setting: An assisted reproduction center.

Patient(s): A 32-year-old patient with azoospermia.

Intervention(s): Histological testicular biopsy, Y-chromosome screening, FSH treatment, and intracytoplasmic sperm injection.

Main outcome measure(s): Fertilization, embryo development, pregnancy, and delivery.

Result(s): After 6 months of treatment with gonadotropins, a small number of spermatozoa were found in the patient's ejaculate and used for IVF, resulting in a successful twin pregnancy and the delivery of two healthy girls.

Conclusion(s): In this study, treatment with gonadotropins promoted the spermatogenesis process and led to the production of spermatozoa in a normogonadotropic azoospermic patient.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chromosomes, Human, Y*
  • Female
  • Fertilization in Vitro
  • Follicle Stimulating Hormone / therapeutic use*
  • Gene Deletion*
  • Hormones / therapeutic use*
  • Humans
  • Infant, Newborn
  • Male
  • Oligospermia / drug therapy*
  • Oligospermia / genetics*
  • Oligospermia / physiopathology
  • Pregnancy
  • Pregnancy, Multiple
  • Sperm Injections, Intracytoplasmic
  • Spermatogenesis / drug effects
  • Twins


  • Hormones
  • Follicle Stimulating Hormone