Epidermal growth factor contamination and concentrations of intact human chorionic gonadotropin in commercial preparations

Sarah J Yarram; Julian Jenkins; Lawrence A Cole; Nathan L Brown; Jonathan R Sandy; Jason P Mansell

doi:10.1016/j.fertnstert.2003.11.051

Epidermal growth factor contamination and concentrations of intact human chorionic gonadotropin in commercial preparations

Fertil Steril. 2004 Jul;82(1):232-3. doi: 10.1016/j.fertnstert.2003.11.051.

Authors

Sarah J Yarram, Julian Jenkins, Lawrence A Cole, Nathan L Brown, Jonathan R Sandy, Jason P Mansell

PMID: 15237021
DOI: 10.1016/j.fertnstert.2003.11.051

Abstract

It is well-known that many urinary-derived human chorionic gonadotropin (hCG) preparations contain a variety of contaminating agents that may influence the efficacy and possible safety of their application. Herein, we report the finding of epidermal growth factor (EGF) contamination and high hCG beta core levels in two leading brands of hCG - findings that will promote the use of recombinant hCG instead of the cruder, urinary-derived formulations.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Chorionic Gonadotropin* / analysis
Drug Compounding
Drug Contamination*
Drug Industry
Epidermal Growth Factor*
Humans
Osmolar Concentration

Substances

Chorionic Gonadotropin
Epidermal Growth Factor