Glyco-dependent nuclear import of glycoproteins, glycoplexes and glycosylated plasmids

Michel Monsigny; Christine Rondanino; Eric Duverger; Isabelle Fajac; Annie-Claude Roche

doi:10.1016/j.bbagen.2004.03.015

Glyco-dependent nuclear import of glycoproteins, glycoplexes and glycosylated plasmids

Biochim Biophys Acta. 2004 Jul 6;1673(1-2):94-103. doi: 10.1016/j.bbagen.2004.03.015.

Authors

Michel Monsigny¹, Christine Rondanino, Eric Duverger, Isabelle Fajac, Annie-Claude Roche

Affiliation

¹ Glycobiologie, Vectorologie et Trafic Intracellulaire, Centre de Biophysique Moléculaire, Centre National de la Recherche Scientifique, 1 rue Charles-Sadron, F-45071 Orléans Cedex 2, France. monsigny@cnrs-orleans.fr

PMID: 15238252
DOI: 10.1016/j.bbagen.2004.03.015

Abstract

This short review deals with some properties of nuclear sugar-binding proteins also called nuclear lectins, the sugar-dependent nuclear import of neoglycoproteins and the attempts of using this pathway to enhance the nuclear import of plasmids in order to hopefully increase the expression of transferred genes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biological Transport
Cell Nucleus / metabolism*
Genetic Therapy
Glycoproteins / metabolism*
Glycosylation
Humans
Lectins / metabolism*
Mannosides
Microinjections
Plasmids / metabolism*
Pyrrolidonecarboxylic Acid

Substances

Glycoproteins
Lectins
Mannosides
Pyrrolidonecarboxylic Acid