Airway eicosanoids in acute severe respiratory syncytial virus bronchiolitis

J Pediatr. 2004 Jul;145(1):115-8. doi: 10.1016/j.jpeds.2004.03.049.


We prospectively studied the levels of eicosanoids in intubated patients with severe bronchiolitis and compared them to electively intubated non-infected infants. LeukotrieneE(4) (LTE(4)), leukotrieneB(4) (LTB(4)), and prostaglandinE(2) (PGE(2)) levels were significantly increased (P <.01) from endotracheal (ET) aspirates of infants with bronchiolitis compared with controls, as were urinary LTE(4) levels (P <.001). We conclude that eicosanoids are increased in the tracheal aspirates and urine of children with bronchiolitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Bronchiolitis, Viral / metabolism*
  • Case-Control Studies
  • Child, Preschool
  • Dinoprostone / metabolism*
  • Female
  • Humans
  • Infant
  • Intubation, Intratracheal
  • Leukotriene B4 / metabolism*
  • Leukotriene E4 / metabolism*
  • Male
  • Prospective Studies
  • Respiratory Syncytial Virus Infections / metabolism*


  • Leukotriene B4
  • Leukotriene E4
  • Dinoprostone