Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 89 (7), 3183-8

Hormonal Manipulation of Benign Metastasizing Leiomyomas: Report of Two Cases and Review of the Literature

Affiliations
Review

Hormonal Manipulation of Benign Metastasizing Leiomyomas: Report of Two Cases and Review of the Literature

J A Rivera et al. J Clin Endocrinol Metab.

Abstract

Benign metastasizing leiomyomas (BMLs) occur predominantly in women during reproductive years. The condition is characterized by uterine leiomyomas associated with the development, typically years later, of slow-growing metastatic lesions. The most commonly affected organs are the lungs, but BMLs have been reported in lymph nodes, deep soft tissues, mesentery, bones, the central nervous system, and the heart. In many cases, these lesions have an indolent course and are discovered rather incidentally. However, occasionally they can present with debilitating symptoms or even life-threatening complications. The presence of estrogen and progesterone receptors in these tumors supports their origin from uterine smooth muscle and, more importantly, makes them amenable to hormonal manipulation. Radical interventions, such as extensive tumor debulking and oophorectomy for hormonal control, although effective in many cases, are not always possible or desirable and carry significant morbidity. Here we present two cases of BMLs to illustrate the role of newer therapeutic agents, the estrogen receptor modulators and the aromatase inhibitors, in the hormonal manipulation of these tumors.

Similar articles

See all similar articles

Cited by 40 articles

See all "Cited by" articles

Publication types

MeSH terms

Feedback