Anti-inflammatory constituents of Mortonia greggii Gray

Z Naturforsch C J Biosci. 2004 Mar-Apr;59(3-4):237-43. doi: 10.1515/znc-2004-3-421.

Abstract

A new phytochemical study of Mortonia greggii (Celastraceae) afforded four friedelan derivatives (1-4), three lupanes (5-7), retusine (8), two esterified polyhydroxyagarofurans (9-10), mortonin C (11) and photomortonin C (12). The anti-inflammatory activity on carrageenan and 12-O-tetradecanoylphorbol-13-acetate induced models of inflammation, as well as the ability to inhibit the nitric oxide (NO) produced by lipopolysaccharide-stimulated mouse peritoneal macrophages were evaluated for the main metabolites. Our results showed that the friedelan dehydrocanophyllic acid methyl ester (1) exhibits an anti-inflammatory effect which could be related to an inhibition of prostaglandin and NO production. The activity of lupeol (5), 29-hydroxylupeol (6) and 29-hydroxylupenone (7) might be involved with the prostanoid synthesis. The presence of the hydroxy groups in 6 appears to be important for activity. The edema inhibition capacity of retusine (8) could be related to a reduction of the prostaglandin production. The agarofuran derivative 10 is an NO inhibitor whose activity is probably not involved in the synthesis of prostaglandins.

MeSH terms

  • Acetone
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Carrageenan
  • Celastraceae / chemistry*
  • Ear
  • Edema / chemically induced
  • Edema / prevention & control*
  • Extremities
  • Furans / chemistry*
  • Furans / isolation & purification
  • Furans / pharmacology
  • Macrophage Activation / drug effects
  • Macrophage Activation / physiology
  • Mice
  • Mice, Inbred Strains
  • Molecular Conformation
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Leaves / chemistry
  • Plant Roots / chemistry
  • Rats
  • Rats, Wistar
  • Tetradecanoylphorbol Acetate

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Furans
  • Plant Extracts
  • Acetone
  • Nitric Oxide
  • Carrageenan
  • Tetradecanoylphorbol Acetate