Adiponectin and the systemic inflammatory response in weight-losing patients with non-small cell lung cancer

Cytokine. 2004 Jul 21-Aug 7;27(2-3):90-2. doi: 10.1016/j.cyto.2004.03.017.


The aim of the present study was to examine the relationship between adiponectin and the systemic inflammatory response in weight-losing patients with non-small cell lung cancer (NSCLC). Measurement of anthropometry, acute phase proteins, interleukin-6, leptin (total and free) and adiponectin were carried out on healthy subjects (n = 13) and non-small cell lung cancer patients with weight loss (n = 20). The groups were age and sex matched. Compared with the controls the cancer group had a lower BMI (p < 0.01), mid-upper arm circumference (p < 0.001), triceps skinfold thickness (p < 0.05) and circulating concentrations of albumin (p < 0.001), haemoglobin (p < 0.05), free and total leptin (p < 0.05) and adiponectin (p < 0.01). In contrast, the cancer group had elevated circulating concentrations of interleukin-6 and C-reactive protein concentrations (p < 0.001). In the cancer group circulating adiponectin concentrations were significantly inversely correlated with both free (rs = -0.675, p = 0.001) and total leptin concentrations (rs = -0.690, p = 0.001). However, neither weight loss, interleukin-6 or C-reactive protein concentrations were correlated with either adiponectin, free or total leptin concentrations in the cancer group. These results suggest that adipokine production is normal and is unlikely to play a major role in the abnormal fat metabolism in weight-losing cancer patients.

MeSH terms

  • Adiponectin
  • Aged
  • Body Mass Index*
  • C-Reactive Protein / analysis
  • Carcinoma, Non-Small-Cell Lung / blood*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Fats / metabolism
  • Female
  • Humans
  • Inflammation
  • Intercellular Signaling Peptides and Proteins / blood*
  • Leptin / blood
  • Lung Neoplasms / blood*
  • Lung Neoplasms / pathology
  • Male
  • Middle Aged
  • Weight Loss*


  • Adiponectin
  • Fats
  • Intercellular Signaling Peptides and Proteins
  • Leptin
  • C-Reactive Protein