Long-term Effects of Immunization With Recombinant Lipoprotein Outer Surface Protein a on Serologic Test for Lyme Disease

Clin Diagn Lab Immunol. 2004 Jul;11(4):808-10. doi: 10.1128/CDLI.11.4.808-810.2004.

Abstract

Immunization with recombinant lipoprotein outer surface protein A vaccine is known to interfere with some serologic tests for Lyme disease. We tested sera from 152 vaccine recipients by using in-house and commercial Western blot assays and found that vaccination caused interference in up to 25% of recipients and can persist for over 6 years.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antigens, Surface / immunology*
  • Bacterial Outer Membrane Proteins / immunology*
  • Bacterial Vaccines
  • Blotting, Western
  • Borrelia burgdorferi / immunology
  • Cross Reactions / immunology
  • Enzyme-Linked Immunosorbent Assay
  • False Positive Reactions
  • Humans
  • Immunoglobulin G / immunology
  • Lipoproteins / immunology*
  • Lyme Disease / diagnosis*
  • Recombinant Proteins / immunology
  • Serologic Tests / standards*
  • Time Factors
  • Vaccination / adverse effects*

Substances

  • Antigens, Surface
  • Bacterial Outer Membrane Proteins
  • Bacterial Vaccines
  • Immunoglobulin G
  • Lipoproteins
  • OspA protein
  • Recombinant Proteins