Exercise training and sympathetic regulation in experimental heart failure

Exerc Sport Sci Rev. 2004 Jul;32(3):107-11. doi: 10.1097/00003677-200407000-00006.

Abstract

In this review, we put forth the hypothesis that reduction in sympathetic outflow after exercise training of animals with heart failure is mediated by reductions in angiotensin II and in angiotensin type 1 receptors. Furthermore, we provide evidence that exercise training provides for an upregulation of the neuronal isoform of nitric oxide synthase in the central nervous system that is sympathoinhibitory.

Publication types

  • Review

MeSH terms

  • Angiotensin II / metabolism
  • Animals
  • Baroreflex / physiology
  • Disease Models, Animal
  • Heart Failure / enzymology
  • Heart Failure / metabolism
  • Heart Failure / physiopathology*
  • Nitric Oxide / metabolism
  • Nitric Oxide Synthase / metabolism
  • Physical Conditioning, Animal / physiology*
  • Rabbits
  • Receptor, Angiotensin, Type 1 / metabolism
  • Sympathetic Nervous System / physiopathology*

Substances

  • Receptor, Angiotensin, Type 1
  • Angiotensin II
  • Nitric Oxide
  • Nitric Oxide Synthase