Abstract
In this review, we put forth the hypothesis that reduction in sympathetic outflow after exercise training of animals with heart failure is mediated by reductions in angiotensin II and in angiotensin type 1 receptors. Furthermore, we provide evidence that exercise training provides for an upregulation of the neuronal isoform of nitric oxide synthase in the central nervous system that is sympathoinhibitory.
Copyright 2004 American College of Sports Medicine
MeSH terms
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Angiotensin II / metabolism
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Animals
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Baroreflex / physiology
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Disease Models, Animal
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Heart Failure / enzymology
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Heart Failure / metabolism
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Heart Failure / physiopathology*
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Nitric Oxide / metabolism
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Nitric Oxide Synthase / metabolism
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Physical Conditioning, Animal / physiology*
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Rabbits
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Receptor, Angiotensin, Type 1 / metabolism
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Sympathetic Nervous System / physiopathology*
Substances
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Receptor, Angiotensin, Type 1
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Angiotensin II
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Nitric Oxide
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Nitric Oxide Synthase