Controlled ultrasound tissue erosion

IEEE Trans Ultrason Ferroelectr Freq Control. 2004 Jun;51(6):726-36. doi: 10.1109/tuffc.2004.1308731.


The ability of ultrasound to produce highly controlled tissue erosion was investigated. This study is motivated by the need to develop a noninvasive procedure to perforate the neonatal atrial septum as the first step in treatment of hypoplastic left heart syndrome. A total of 232 holes were generated in 40 pieces of excised porcine atrial wall by a 788 kHz single-element transducer. The effects of various parameters [e.g., pulse repetition frequency (PRF), pulse duration (PD), and gas content of liquid] on the erosion rate and energy efficiency were explored. An Isppa of 9000 W/cm2, PDs of 3, 6, 12, and 24 cycles; PRFs between 1.34 kHz and 66.7 kHz; and gas saturation of 40-55% and 79-85% were used. The results show that very short pulses delivered at certain PRFs could maximize the erosion rate and energy efficiency. We show that well-defined perforations can be precisely located in the atrial wall through the controlled ultrasound tissue erosion (CUTE) process. A preliminary in vivo experiment was conducted on a canine subject, and the atrial septum was perforated using CUTE.

Publication types

  • Evaluation Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Dogs
  • Dose-Response Relationship, Radiation
  • Feasibility Studies
  • Heart Atria / radiation effects*
  • Heart Atria / surgery*
  • Heart Septum / radiation effects*
  • Heart Septum / surgery*
  • In Vitro Techniques
  • Lithotripsy / methods*
  • Minimally Invasive Surgical Procedures / methods*
  • Ultrasonic Therapy / methods*
  • Ultrasonics*