Linezolid-associated peripheral neuropathy

Mayo Clin Proc. 2004 Jul;79(7):927-30. doi: 10.4065/79.7.927.


Linezolid is the first drug in a new class of synthetic antimicrobials, the oxazolidinones, to be approved by the Food and Drug Administration. Linezolid is active against methicillin- and vancomycin-resistant gram-positive microorganisms. We describe 2 patients who developed peripheral neuropathy after prolonged treatment with linezolid. Linezolid-associated peripheral neuropathy has not been well documented. Most reported cases of linezolid-associated peripheral neuropathy have occurred in patients who took linezolid for a period longer than the recommended 28 or fewer days. Health care providers must be alert to the potential for serious adverse effects associated with linezolid use, including peripheral neuropathy.

Publication types

  • Case Reports

MeSH terms

  • Acetamides / adverse effects*
  • Adult
  • Aged
  • Anti-Infective Agents / adverse effects*
  • Humans
  • Linezolid
  • Male
  • Oxazolidinones / adverse effects*
  • Peripheral Nervous System Diseases / chemically induced*
  • Surgical Wound Infection


  • Acetamides
  • Anti-Infective Agents
  • Oxazolidinones
  • Linezolid