Pyoderma gangrenosum associated with Takayasu's arteritis

Clin Exp Dermatol. 2004 Jul;29(4):357-9. doi: 10.1111/j.1365-2230.2004.01514.x.


Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterized by destructive, necrotizing and noninfective ulceration of the skin mostly on lower extremities. PG is well known as a complication of Takayasu's arteritis in Japan. However, this association is not commonly observed in North American and European patients. We describe a case of PG that was associated with Takayasu's arteritis who was successfully treated with systemic cyclosporin. We have reviewed 35 well-documented PG cases with Takayasu's arteritis in comparison to 106 PG cases without Takayasu's arteritis. The results demonstrate that this association occurs predominantly in young females and that these cases exhibit more widespread PG lesions.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Cyclosporine / therapeutic use
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Pyoderma Gangrenosum / drug therapy
  • Pyoderma Gangrenosum / etiology*
  • Pyoderma Gangrenosum / pathology
  • Takayasu Arteritis / complications*
  • Takayasu Arteritis / pathology


  • Immunosuppressive Agents
  • Cyclosporine