Toll-like receptors and microbes take aim at each other

Curr Opin Immunol. 2004 Aug;16(4):483-7. doi: 10.1016/j.coi.2004.05.012.

Abstract

Toll-like receptors (TLRs) are key components of effective innate immunity. As such, pathogenic microorganisms must evade recognition by TLRs, manipulate the consequences of TLR activation, or contend with the inflammatory consequences of TLR activation. Recent studies have improved our understanding of the various mechanisms by which pathogenic organisms manipulate the TLR recognition system.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacteria / immunology*
  • Bacterial Infections / immunology*
  • Bacterial Infections / microbiology
  • Bacterial Proteins / immunology
  • Candida albicans / immunology*
  • Candidiasis / immunology*
  • Fungal Proteins / immunology
  • Humans
  • Immunity, Innate*
  • Membrane Glycoproteins / immunology*
  • Mice
  • Receptors, Cell Surface / immunology*
  • Signal Transduction / immunology
  • Toll-Like Receptors

Substances

  • Bacterial Proteins
  • Fungal Proteins
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors