Chemokines in neoplastic progression

Semin Cancer Biol. 2004 Jun;14(3):181-5. doi: 10.1016/j.semcancer.2003.10.004.


Chemokines and their receptors have emerged as attractive targets regulating the migration of tumor cells in vivo, a process known as cancer metastasis. The control of metastasis is critical to the control of cancer progression. Two chemokine receptors and their ligands stand out as likely targets for therapeutics: CCR7/CCL21 for lymph node metastases, and CXCR4/CXCL12 for lung, liver, bone marrow, and brain metastases. The most widely expressed chemokine receptor among cancers is likely to be CXCR4.

Publication types

  • Review

MeSH terms

  • Chemokines / physiology*
  • Disease Progression
  • Humans
  • Neoplasms / physiopathology*
  • Receptors, Chemokine / metabolism


  • Chemokines
  • Receptors, Chemokine