Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c

J Clin Epidemiol. 2004 Jun;57(6):590-6. doi: 10.1016/j.jclinepi.2003.10.007.


Objective: To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality.

Study design and setting: A joint analysis of two prospective studies with baseline glycemia measurements.

Results: The multivariate adjusted hazard ratios (HRs) corresponding to a one standard deviation increase in HbA1c were 1.14 (95% CI 1.03-1.25), 1.08 (0.98-1.19) for FPG and 1.15 (1.05-1.27) for 2-hr glucose, respectively. Entering the 2-hr glucose to the model based on the FPG and HbA1c significantly improved the prediction of mortality, whereas neither FPG, nor HbA1c added significant information once 2-hr glucose was in the models. In subjects with FPG <7.0 mmol/L and HbA1c < or = 6.5%, the HR was 1.35 (1.03-1.78) in men with 2-hr glucose > or = 7.8 mmol/L compared with men with 2-hr glucose <7.8 mmol/L.

Conclusion: Elevated 2-hr glucose was a predictor of mortality independent of the levels of fasting glucose and HbA1c.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Blood Glucose / analysis*
  • Cause of Death
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / mortality*
  • Fasting
  • Glucose Tolerance Test
  • Glycated Hemoglobin A / analysis
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Proportional Hazards Models
  • Prospective Studies


  • Blood Glucose
  • Glycated Hemoglobin A