Linking tumor suppression, DNA damage and the anaphase-promoting complex

Peter K Jackson

doi:10.1016/j.tcb.2004.05.005

Linking tumor suppression, DNA damage and the anaphase-promoting complex

Trends Cell Biol. 2004 Jul;14(7):331-4. doi: 10.1016/j.tcb.2004.05.005.

Author

Peter K Jackson¹

Affiliation

¹ Stanford University School of Medicine, 300 Pasteur Drive, Palo Alto, CA 94305, USA. pjackson@stanford.edu

PMID: 15246424
DOI: 10.1016/j.tcb.2004.05.005

Abstract

A recent study shows that the RASSF1A tumor suppressor functions as a regulator of the ordered proteolytic steps that organize mitosis. By controlling the stability of microtubules and the activity of the anaphase-promoting complex (APC), RASSF1A might provide a crucial link between mechanisms of tumor suppression and mitotic cell division. Furthermore, another recent study shows that protein kinase A, which is a key growth regulator, inhibits the APC during mitosis in yeast.

Publication types

Review

MeSH terms

Anaphase-Promoting Complex-Cyclosome
Cyclic AMP-Dependent Protein Kinases / pharmacology
DNA Damage / physiology*
Humans
Mitosis / physiology
Tumor Suppressor Proteins / metabolism*
Ubiquitin-Protein Ligase Complexes / antagonists & inhibitors
Ubiquitin-Protein Ligase Complexes / metabolism*
Yeasts / enzymology

Substances

RASSF1 protein, human
Tumor Suppressor Proteins
Ubiquitin-Protein Ligase Complexes
Anaphase-Promoting Complex-Cyclosome
Cyclic AMP-Dependent Protein Kinases