Accuracy of the triglyceride to high-density lipoprotein cholesterol ratio for prediction of the low-density lipoprotein phenotype B

Am J Cardiol. 2004 Jul 15;94(2):219-22. doi: 10.1016/j.amjcard.2004.03.069.


This study examined the accuracy of a triglyceride/high-density lipoprotein (HDL) cholesterol ratio of 3.8 for the prediction of low-density lipoprotein (LDL) phenotype B. The ratio of 3.8 was based on Adult Treatment Panel recommendations for normal fasting triglycerides (<150 mg/dl) and HDL cholesterol (>40 mg/dl). Fasting blood samples were obtained from 658 patients. LDL phenotype analysis was performed by nuclear magnetic resonance spectroscopy. A triglyceride/HDL cholesterol ratio of 3.8 divided the distribution of LDL phenotypes with 79% (95% confidence interval [CI] 74 to 83) of phenotype B greater than and 81% (95% CI 77 to 85) of phenotype A less than the ratio of 3.8. The ratio was reliable for identifying LDL phenotype B in men and women.

MeSH terms

  • Aged
  • Cholesterol, HDL / blood*
  • Cholesterol, LDL / genetics*
  • Female
  • Humans
  • Logistic Models
  • Magnetic Resonance Spectroscopy
  • Male
  • Middle Aged
  • Particle Size
  • Phenotype
  • Sensitivity and Specificity
  • Triglycerides / blood*


  • Cholesterol, HDL
  • Cholesterol, LDL
  • Triglycerides