Prognostic importance of renal function in patients with early heart failure and mild left ventricular dysfunction

Am J Cardiol. 2004 Jul 15;94(2):240-3. doi: 10.1016/j.amjcard.2004.03.075.


We evaluated the prognostic value of renal function in an initially "untreated" population with mild heart failure and compared the prognosis of this population with a matched controlled population. During a follow-up of 13 years (mean 11.7), 90 patients (56%) died. Mortality was higher compared with a matched controlled population. Multivariate Cox regression analysis demonstrated that beside the well-established risk markers of left ventricular ejection fraction and heart rate, renal function (estimated glomerular filtration rate, hazard ratio 1.16/10 ml/min/1.73 m(2), p = 0.003) was the only additional independent predictor of cardiovascular mortality in patients with early heart failure.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Clinical Trials as Topic
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate
  • Heart Failure / mortality*
  • Heart Failure / physiopathology
  • Humans
  • Kidney / physiopathology*
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Multivariate Analysis
  • Netherlands / epidemiology
  • Prognosis
  • Risk Factors
  • Survival Analysis
  • Ventricular Dysfunction, Left / mortality*
  • Ventricular Dysfunction, Left / physiopathology