Impact of one year of shift work on cardiovascular disease risk factors

J Occup Environ Med. 2004 Jul;46(7):699-706. doi: 10.1097/01.jom.0000131794.83723.45.


The purpose of the study was to investigate whether the reported increased cardiovascular disease risk in shift workers could be explained by changes in cardiovascular risk factors. In a cohort of 239 shift and 157 daytime workers, 1-year changes in biological and lifestyle cardiovascular risk factors were monitored between the start of a new job and 1 year later. Both body mass index and low-density lipoprotein/high-density lipoprotein cholesterol ratio decreased significantly in shift workers compared with daytime workers (body mass index change: -0.31 and +0.13 kg/m; low-density lipoprotein/high-density lipoprotein ratio change: -0.33 and -0.13 respectively). Cigarettes smoked per day increased significantly in shift compared with daytime workers (+1.42 and -1.03, respectively). Therefore, only for smoking, an unfavorable change was observed. This may explain, at most, only a part of the excess cardiovascular disease risk reported in shift workers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Body Mass Index
  • Cardiovascular Diseases / etiology*
  • Cohort Studies
  • Female
  • Humans
  • Life Style
  • Lipoproteins / blood
  • Male
  • Personnel Staffing and Scheduling*
  • Risk Factors
  • Smoking / adverse effects


  • Lipoproteins