A role for Streptococcus pneumoniae in virus-associated pneumonia

Nat Med. 2004 Aug;10(8):811-3. doi: 10.1038/nm1077. Epub 2004 Jul 11.

Abstract

Here we show, in a double-blind, randomized, placebo-controlled trial in 37,107 fully immunized infants in Soweto, South Africa, that a 9-valent pneumococcal conjugate vaccine, PncCV, prevents 31% (95% confidence interval = 15-43%) of pneumonias associated with any of seven respiratory viruses in children in hospital. These data suggest that the pneumococcus has a major role in the development of pneumonia associated with these viruses and that viruses contribute to the pathogenesis of bacterial pneumonia.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Double-Blind Method
  • HIV Infections / complications*
  • Haemophilus Vaccines
  • Humans
  • Infant
  • Pneumococcal Vaccines / immunology*
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / etiology*
  • Pneumonia, Viral / immunology
  • Respiratory Syncytial Viruses / immunology*
  • South Africa
  • Streptococcus pneumoniae / immunology*
  • Streptococcus pneumoniae / isolation & purification
  • Vaccines, Conjugate / immunology

Substances

  • Haemophilus Vaccines
  • Pneumococcal Vaccines
  • Vaccines, Conjugate