Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 118 (5), 294-306

Mitochondrial DNA Control Region Sequences From Nairobi (Kenya): Inferring Phylogenetic Parameters for the Establishment of a Forensic Database

Affiliations

Mitochondrial DNA Control Region Sequences From Nairobi (Kenya): Inferring Phylogenetic Parameters for the Establishment of a Forensic Database

Anita Brandstätter et al. Int J Legal Med.

Abstract

Large forensic mtDNA databases which adhere to strict guidelines for generation and maintenance, are not available for many populations outside of the United States and western Europe. We have established a high quality mtDNA control region sequence database for urban Nairobi as both a reference database for forensic investigations, and as a tool to examine the genetic variation of Kenyan sequences in the context of known African variation. The Nairobi sequences exhibited high variation and a low random match probability, indicating utility for forensic testing. Haplogroup identification and frequencies were compared with those reported from other published studies on African, or African-origin populations from Mozambique, Sierra Leone, and the United States, and suggest significant differences in the mtDNA compositions of the various populations. The quality of the sequence data in our study was investigated and supported using phylogenetic measures. Our data demonstrate the diversity and distinctiveness of African populations, and underline the importance of establishing additional forensic mtDNA databases of indigenous African populations.

Similar articles

See all similar articles

Cited by 27 PubMed Central articles

See all "Cited by" articles

References

    1. Am J Hum Genet. 2000 Aug;67(2):444-61 - PubMed
    1. Ann Hum Biol. 1993 Sep-Oct;20(5):477-85 - PubMed
    1. J Mol Evol. 1993 Oct;37(4):347-54 - PubMed
    1. Genetics. 1997 Dec;147(4):1959-64 - PubMed
    1. Nature. 1981 Apr 9;290(5806):457-65 - PubMed

Substances

LinkOut - more resources

Feedback