Apterous is a Drosophila LIM domain gene required for the development of a subset of embryonic muscles

Neuron. 1992 Sep;9(3):549-61. doi: 10.1016/0896-6273(92)90192-g.

Abstract

The recently discovered LIM motif is found in a set of homeodomain-containing proteins thought to mediate the generation of particular cell types. Of the four LIM domain family members described to date, mec-3 and lin-11 determine cell lineages in C. elegans. Isl-1 and Xlim-1 may play similar roles in vertebrates. We have identified a Drosophila member of this class, the product of the apterous (ap) gene. During embryogenesis, ap is expressed in a small subset of fusing mesodermal precursors that give rise to 6 muscles in each abdominal hemisegment and in 5 neurons within each corresponding CNS hemisegment. Lack of ap function results in loss of ap-expressing muscles, while misexpression of ap using a heterologous promoter produces ectopic muscles.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Central Nervous System / embryology
  • Choristoma / genetics
  • Drosophila / embryology
  • Drosophila / genetics*
  • Embryonic and Fetal Development*
  • Enhancer Elements, Genetic
  • Gene Expression
  • Genes*
  • Genetic Techniques
  • Mesoderm / physiology
  • Molecular Sequence Data
  • Muscles / embryology*
  • Peripheral Nerves / embryology

Associated data

  • GENBANK/M92841