Nucleotide sequence of a cDNA encoding murine fumarylacetoacetate hydrolase

Biochem Med Metab Biol. 1992 Aug;48(1):26-31. doi: 10.1016/0885-4505(92)90044-y.


Hereditary tyrosinemia type I is caused by deficiency of the enzyme fumarylacetoacetate hydrolase (FAH) (EC, the final step in tyrosine degradation. We report here the cloning and sequencing of a full length cDNA coding for murine FAH. This cDNA is highly homologous to the previously cloned human and rat genes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA / chemistry*
  • Humans
  • Hydrolases / genetics*
  • Mice
  • Molecular Sequence Data
  • Rats


  • DNA
  • Hydrolases
  • fumarylacetoacetase

Associated data

  • GENBANK/Z11774