[Epidemiological study of nasopharyngeal carcinoma risk in relatives of high-risk families in Guangdong]

Ai Zheng. 2004 Jul;23(7):767-70.
[Article in Chinese]


Background & objective: Familial clustering of NPC has been widely observed, however, related investigations were mainly involved in individual reports for high-risk families or case-control study with small sample size, so no quantitive evaluation for NPC risk in relatives of high-risk families documented in high-risk area until now. The purpose of the study was to estimate NPC risk among relatives of high-risk pedigrees in Guangong province, so as to provide information for genetic epidemiology and clinical genetic consultation.

Methods: One hundred and thirteen high-risk pedigrees were collected in the Cancer Center of Sun Yat-sen University, and standardized incidence ratio (SIR) was used to estimate NPC risk of first degree relatives (FDR).

Results: NPC risk was significantly higher in first degree relatives that in general population, and SIR was 37.55; in addition, SIRs were 50.72, 79.64, 7.12, and 33.58 in their brothers, sisters, fathers, and mothers respectively.

Conclusion: NPC risk of relatives in familial NPC pedigrees elevates 7.12 to 79.64 times in high-risk families.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • China / epidemiology
  • Family Health
  • Female
  • Genetic Predisposition to Disease*
  • Humans
  • Male
  • Nasopharyngeal Neoplasms / epidemiology*
  • Nasopharyngeal Neoplasms / genetics*
  • Pedigree
  • Risk Factors