Association of Streptococcus bovis bacteremia with colonic neoplasia and extracolonic malignancy

Arch Surg. 2004 Jul;139(7):760-5. doi: 10.1001/archsurg.139.7.760.

Abstract

Background: The association between Streptococcus bovis bacteremia and colonic neoplasia is well described; however, the relationship between S bovis and neoplasia outside the colon has not been well evaluated.

Hypothesis: S bovis bacteremia may be associated with colonic neoplasia and extracolonic malignancy.

Design: Retrospective review of all documented cases of S bovis bacteremia identified by a search of computerized bacteriology records.

Setting: One tertiary referral hospital and 1 community hospital located in the same city.

Patients: Forty-five patients (41 adults, 4 children) with documented S bovis bacteremia during a 12-year period were identified.

Main outcome measures: Available patient records were reviewed to identify the presence of colonic neoplasia, the use of gastrointestinal endoscopy, and the presence of gastrointestinal or extraintestinal malignancies.

Results: Seventeen patients (41% of adult patients) underwent colonoscopy. Colonic neoplasia was present in 16 patients (39% of adults), with 3 of these patients having invasive colorectal cancer (7% of adults). Invasive cancer was present in 13 patients (32% of adults). Eight patients had malignant lesions arising within the gastrointestinal tract, and 5 patients had extraintestinal malignancies.

Conclusion: S bovis bacteremia is associated with both colonic neoplasia and extracolonic malignancy.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Bacteremia / epidemiology*
  • Child, Preschool
  • Colonic Neoplasms / epidemiology*
  • Colonic Neoplasms / microbiology
  • Colonoscopy
  • Comorbidity
  • Endoscopy, Gastrointestinal
  • Female
  • Gastrointestinal Neoplasms / epidemiology
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Neoplasms / epidemiology*
  • Neoplasms / microbiology
  • Retrospective Studies
  • Streptococcal Infections / epidemiology*
  • Streptococcus bovis*