Abnormal estrogen receptor in clinical breast cancer

J Steroid Biochem Mol Biol. 1992 Sep;43(1-3):243-7. doi: 10.1016/0960-0760(92)90214-4.


We have discovered a number of estrogen receptor variants in clinical breast cancer tissues. We have base-pair insertions, transitions, and deletions of exons 3, 5 and 7. Using a transactivation assay we have discovered receptors with outlaw function consisting of both dominant-positive receptors which are transcriptionally active in the absence of estrogen, and dominant-negative receptors which are transcriptionally inactive themselves but prevent normal estrogen receptor function.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism
  • Mutation*
  • Phenotype
  • Receptors, Estrogen / genetics*
  • Receptors, Estrogen / metabolism


  • Receptors, Estrogen