Inhibition of IL-6 for the treatment of inflammatory diseases

Curr Opin Pharmacol. 2004 Aug;4(4):386-91. doi: 10.1016/j.coph.2004.03.005.


Interleukin-6 (IL-6) is a pleiotropic cytokine with various biological activities. Deregulated overproduction of IL-6 has been found to play pathological roles in chronic inflammatory diseases such as rheumatoid arthritis, Castleman's disease, juvenile idiopathic arthritis and Crohn's disease. Humanized anti-IL-6 receptor antibody has been developed as a therapeutic agent for these diseases, and therapeutic benefits have been revealed in clinical studies.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies / therapeutic use
  • Arthritis, Rheumatoid / therapy
  • Castleman Disease / therapy
  • Crohn Disease / therapy
  • Humans
  • Inflammation / therapy*
  • Interleukin-6 / antagonists & inhibitors*
  • Interleukin-6 / physiology
  • Receptors, Interleukin-6 / antagonists & inhibitors
  • Still's Disease, Adult-Onset / therapy


  • Antibodies
  • Interleukin-6
  • Receptors, Interleukin-6