Developmental differences in nicotine place conditioning

Ann N Y Acad Sci. 2004 Jun;1021:399-403. doi: 10.1196/annals.1308.052.


To understand the motivations and implications of the prevalence of smoking, studies have compared the behavioral effects of nicotine, the psychoactive drug in tobacco, in adolescent and adult animals. The present study used a biased three-chambered conditioned-place preference procedure without prior habituation to examine the potential rewarding and anxiolytic effects of nicotine across adolescence and adulthood to assess the presence of age-dependent differences in response to nicotine.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Analysis of Variance
  • Animals
  • Animals, Newborn
  • Behavior, Animal
  • Choice Behavior / drug effects
  • Conditioning, Operant / drug effects*
  • Female
  • Male
  • Motivation*
  • Nicotine / pharmacology*
  • Nicotinic Agonists / pharmacology*
  • Rats
  • Rats, Sprague-Dawley


  • Nicotinic Agonists
  • Nicotine