The production and localization of GTP-bound ran in mitotic mammalian tissue culture cells

Cell Cycle. 2004 Aug;3(8):993-5. Epub 2004 Aug 25.


The RanGTPase system has multiple functions in both interphase and mitosis. Extensive studies of Ran-driven nucleocytoplasmic transport have contributed significantly toward our understanding of how RanGTP is produced, hydrolyzed, and localized in interphase. However, there is still a lack of understanding about how this system operates in mitosis. Recent advances have begun to shed light on how RanGTP is produced and localized in mitotic mammalian cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Line
  • Cell Nucleus / chemistry
  • Guanosine Triphosphate / metabolism*
  • Humans
  • Mitosis / genetics*
  • ran GTP-Binding Protein / metabolism*


  • Guanosine Triphosphate
  • ran GTP-Binding Protein