The Finger Domain of the Human Deubiquitinating Enzyme HAUSP Is a Zinc Ribbon

Cell Cycle. 2004 Aug;3(8):1046-9. Epub 2004 Aug 8.

Abstract

Human deubiquitinating enzyme HAUSP is a cysteine protease that regulates the levels of the tumor suppressor protein p53. By comparative sequence and structural analysis, we show that the previously uncharacterized finger domain insert to the catalytic core of HAUSP is a zinc ribbon that has lost its zinc-binding ability.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence / genetics
  • Animals
  • Endopeptidases / chemistry*
  • Humans
  • Molecular Sequence Data
  • Protein Structure, Tertiary
  • Sequence Alignment
  • Ubiquitin Thiolesterase
  • Ubiquitin-Specific Peptidase 7
  • Zinc Fingers* / genetics

Substances

  • Endopeptidases
  • USP7 protein, human
  • Ubiquitin Thiolesterase
  • Ubiquitin-Specific Peptidase 7