Analysis of fragrance compounds in blood samples of mice by gas chromatography, mass spectrometry, GC/FTIR and GC/AES after inhalation of sandalwood oil

Biomed Chromatogr. 1992 May-Jun;6(3):133-4. doi: 10.1002/bmc.1130060307.

Abstract

After inhalation experiments with sandalwood oil and the pure fragrance compounds coumarin and alpha-terpineol, substances were detected and measured in the blood samples of test animals (mice) using gas chromatography/mass spectrometry (GC/MS) (MID) in connection with GC/FTIR (SWC), GC/AES (carbon and oxygen trace) and flame ionization detection/gas chromatography. Using tiglinic acid benzyl ester as the internal standard the following concentrations in serum could be found: alpha-santalol 6.1 ng/mL, beta-santalol 5.3 ng/mL and alpha-santalene 0.5 ng/mL. In separate inhalation experiments with coumarin and with alpha-terpineol the corresponding concentrations were 7.7 ng/mL and 6.9 ng/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromatography, Gas
  • Coumarins / analysis*
  • Flame Ionization
  • Gas Chromatography-Mass Spectrometry
  • Mice
  • Odorants / analysis
  • Plant Oils / analysis*
  • Sesquiterpenes / analysis*

Substances

  • Coumarins
  • Plant Oils
  • Sesquiterpenes
  • sandalwood oil