Second messenger signalling in olfaction

Curr Opin Neurobiol. 1992 Aug;2(4):439-43. doi: 10.1016/0959-4388(92)90177-m.


The primary reactions of the chemo-electrical signal transduction pathway in olfactory receptor neurons are mediated by two alternative second messengers, cAMP and inositol 1,4,5-trisphosphate. The rapid and transient intracellular signalling is terminated by the action of negative-feedback loops which uncouple the reaction cascades (desensitization). Recent evidence suggests that secondary reactions in olfaction (adaptation) may also be controlled by second messengers.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Second Messenger Systems / physiology*
  • Signal Transduction / physiology
  • Smell / physiology*