A one-year trial of in-center daily hemodialysis with an emphasis on quality of life

Blood Purif. 2004;22(3):320-8. doi: 10.1159/000079186. Epub 2004 Jun 21.


Background/aims: Hemodialysis is associated with acute changes in several physiologic factors. Previous studies have suggested significant clinical and quality of life (QOL) benefits of daily hemodialysis (DHD) compared with 3 times weekly hemodialysis (CHD). We conducted a prospective trial to evaluate the effects of switching chronic hemodialysis patients to in-center DHD for a 12-month period.

Methods: There were no exclusion criteria. Patients received hemodialysis 6 times per week. The study set a standardized weekly Kt/V (stdKt/V) goal of 3.0. A broad array of clinical parameters was determined. QOL was assessed with multiple instruments.

Results: Eleven subjects completed 12 months and 12 completed 6 months on DHD. Significant changes relative to baseline at 12 months of DHD included decreased BP and improvements in QOL parameters by multiple techniques. 100% of patients at 12 months wished to continue DHD.

Conclusions: DHD offers advantages over CHD with respect to improved QOL and BP control.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Ambulatory Care Facilities*
  • Blood Pressure
  • Female
  • Hematologic Tests
  • Hospitalization
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Quality of Life*
  • Renal Dialysis / methods*
  • Renal Dialysis / psychology*
  • Surveys and Questionnaires
  • Time Factors