Strengths and weaknesses of established indirect models to detect recombinant human erythropoietin abuse on blood samples collected 48-hr post administration

Haematologica. 2004 Jul;89(7):891-2.

Abstract

We studied indirect detection models of erythropoietin abuse (EPO) on blood samples collected 48-hr after administration of the drug during 6 weeks of recombinant human erythropoietin (rHuEPO) treatment. Although the efficiency of OFF-models was preserved, we found a loss of sensitivity of ON-models. This study also revealed an increased percentage of stomatocytes in athletes receiving rHuEPO

Publication types

  • Comment
  • Letter
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Doping in Sports*
  • Erythropoietin / administration & dosage
  • Erythropoietin / blood*
  • Humans
  • Recombinant Proteins
  • Sensitivity and Specificity
  • Substance Abuse Detection / methods*
  • Time Factors

Substances

  • Recombinant Proteins
  • Erythropoietin