Effect of sodium valproate on the secretion of prolactin, cortisol and growth hormone in migraine patients

Cephalalgia. 1992 Aug;12(4):257-8. doi: 10.1046/j.1468-2982.1992.1204257.x.

Abstract

A single oral dose of 500 mg sodium valproate had no effect on prolactin, growth hormone and cortisol secretion in 10 migraine patients when compared with five healthy controls and four migraine patients receiving placebo. Basal values of prolactin (PRL), cortisol and growth hormone (GH) were within the normal range, though PRL basal levels were lower in three patients (21.5%) in the migraine group.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Female
  • Growth Hormone / blood
  • Growth Hormone / metabolism*
  • Humans
  • Hydrocortisone / blood
  • Hydrocortisone / metabolism*
  • Male
  • Middle Aged
  • Migraine Disorders / blood
  • Migraine Disorders / classification
  • Migraine Disorders / metabolism*
  • Prolactin / blood
  • Prolactin / metabolism*
  • Time Factors
  • Valproic Acid / pharmacology*

Substances

  • Valproic Acid
  • Prolactin
  • Growth Hormone
  • Hydrocortisone