Ime2p and Cdc28p: co-pilots driving meiotic development

J Cell Biochem. 2004 Aug 1;92(5):1025-33. doi: 10.1002/jcb.20131.


Meiosis can be considered an elaboration of the cell division cycle in the sense that meiosis combines cell-cycle processes with programs specific to meiosis. Each phase of the cell division cycle is driven forward by cell-cycle kinases (Cdk) and coordinated with other phases of the cycle through checkpoint functions. Meiotic differentiation is also controlled by these two types of regulation; however, recent study in the budding yeast S. cerevisiae indicates that progression of meiosis is also controlled by a master regulator specific to meiosis, namely the Ime2p kinase. Below, I describe the overlapping roles of Ime2p and Cdk during meiosis in yeast and speculate on how these two kinases cooperate to drive the progression of meiosis.

Publication types

  • Review

MeSH terms

  • CDC28 Protein Kinase, S cerevisiae / physiology*
  • Cell Cycle Proteins / physiology*
  • DNA Replication / physiology
  • Intracellular Signaling Peptides and Proteins
  • Meiosis / physiology*
  • Protein Kinases / physiology*
  • Protein Processing, Post-Translational
  • Protein-Serine-Threonine Kinases
  • RNA Processing, Post-Transcriptional
  • Saccharomyces cerevisiae Proteins / physiology*


  • Cell Cycle Proteins
  • Intracellular Signaling Peptides and Proteins
  • Saccharomyces cerevisiae Proteins
  • Protein Kinases
  • IME2 protein, S cerevisiae
  • Protein-Serine-Threonine Kinases
  • CDC28 Protein Kinase, S cerevisiae