Absence of cortical gray matter abnormalities in psychosis of epilepsy: a voxel-based MRI study in patients with temporal lobe epilepsy

J Neuropsychiatry Clin Neurosci. Spring 2004;16(2):148-55. doi: 10.1176/jnp.16.2.148.


The authors retrospectively explored cortical differences between 26 patients with temporal lobe epilepsy and psychosis of epilepsy (POE), 24 patients with temporal lobe epilepsy (TLE) alone, and 20 healthy comparison subjects. Using voxel-based morphometry based on statistical parametric mapping (SPM99), which is an unbiased and fully automated technique to test for morphometric differences, magnetic resonance imaging (MRI) 3D-datasets were acquired and analyzed. There were no significant cortical gray matter differences between the POE and the TLE group. Since cortical pathology is prominent in schizophrenia, POE may be a clinical entity separate from schizophrenia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Cerebral Cortex / abnormalities*
  • Epilepsy, Temporal Lobe / complications
  • Epilepsy, Temporal Lobe / diagnosis*
  • Female
  • Humans
  • In Vitro Techniques
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Normal Distribution
  • Psychotic Disorders / complications
  • Psychotic Disorders / diagnosis*
  • Retrospective Studies