P4 Cap Modified Tetrapeptidyl Alpha-Ketoamides as Potent HCV NS3 Protease Inhibitors

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4333-8. doi: 10.1016/j.bmcl.2004.05.078.

Abstract

We describe herein the design, syntheses, and biological evaluation of new series of P4 tetrazole and adipic acid, ester, amide capped tetrapeptidyl alpha-ketoamide based HCV protease inhibitors.

MeSH terms

  • Amides / chemical synthesis
  • Amides / chemistry
  • Amides / pharmacology*
  • Protease Inhibitors / chemical synthesis
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology*
  • Viral Nonstructural Proteins / antagonists & inhibitors*

Substances

  • Amides
  • NS3 protein, hepatitis C virus
  • Protease Inhibitors
  • Viral Nonstructural Proteins