Antibacterial activity and cytotoxicity of extractives from Ravenia spectabilis

M H Sohrab; R Chowdhury; K M Rahman; C M Hasan; M A Rashid

doi:10.1016/j.fitote.2004.03.008

Antibacterial activity and cytotoxicity of extractives from Ravenia spectabilis

Fitoterapia. 2004 Jul;75(5):510-3. doi: 10.1016/j.fitote.2004.03.008.

Authors

M H Sohrab¹, R Chowdhury, K M Rahman, C M Hasan, M A Rashid

Affiliation

¹ Phytochemical Research Laboratory, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.

PMID: 15261391
DOI: 10.1016/j.fitote.2004.03.008

Abstract

A methanolic extract of Ravenia spectabilis, an isolated alkaloid, arborinine plus a fraction comprising arborinine and gamma-fagarine (VLC), showed mild to significant in vitro antibacterial activity. In a brine shrimp lethality bioassay, the extract and the fraction were found to exhibit moderate cytotoxicity having LC50 of 76.26 microg/ml and 14.98 microg/ml, respectively.

MeSH terms

Animals
Anti-Bacterial Agents / administration & dosage
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Artemia / drug effects
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Humans
Lethal Dose 50
Microbial Sensitivity Tests
Phytotherapy*
Plant Extracts / administration & dosage
Plant Extracts / pharmacology*
Plant Extracts / therapeutic use
Plant Stems
Rutaceae*

Substances

Anti-Bacterial Agents
Plant Extracts