Renal magnesium wasting associated with acetaminophen abuse

Conn Med. 1992 Aug;56(8):421-3.


We report a case of magnesium deficiency associated with acetaminophen abuse. Metabolic studies showed that the patient's fractional excretion of magnesium was 12% when her serum magnesium level was 1.0 mg/dL. Renal biopsy demonstrated severe tubulointerstitial disease. The significant wasting of magnesium at a time when serum magnesium levels were depressed suggests renal magnesium wasting syndrome. This defect was temporally related to abuse of acetaminophen.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetaminophen*
  • Aged
  • Female
  • Humans
  • Injections, Intravenous
  • Magnesium / administration & dosage
  • Magnesium / therapeutic use
  • Magnesium Deficiency / blood
  • Magnesium Deficiency / etiology*
  • Nephritis, Interstitial / chemically induced*
  • Nephritis, Interstitial / complications
  • Substance-Related Disorders / complications*


  • Acetaminophen
  • Magnesium