Hypoxic vasorelaxation: Ca2+-dependent and Ca2+-independent mechanisms

Cell Calcium. Sep-Oct 2004;36(3-4):201-8. doi: 10.1016/j.ceca.2004.02.018.


The mechanisms of oxygen sensing in vascular smooth muscle have been studied extensively in a variety of tissue types and the results of these studies indicate that the mechanism of hypoxia-induced vasodilation probably involves several mechanisms that combined to assure the appropriate response. After a short discussion of the regulatory mechanisms for smooth muscle contractility, we present the evidence indicating that hypoxic vasorelaxation involves both Ca2+-dependent and Ca2+-independent mechanisms. More recent experiments using proteomic approaches in organ cultures of porcine coronary artery reveal important changes evoked by hypoxia in both Ca2+-dependent and Ca2+-independent pathways.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Calcium / physiology*
  • Cell Hypoxia / physiology
  • Humans
  • Muscle, Smooth, Vascular / drug effects
  • Muscle, Smooth, Vascular / metabolism*
  • Ryanodine / pharmacology
  • Vasodilation / drug effects
  • Vasodilation / physiology*


  • Ryanodine
  • Calcium