Ocular effects of endothelin-1 in the cat

Curr Eye Res. 1992 Apr;11(4):325-32. doi: 10.3109/02713689209001786.


The effects of intravitreal and intracameral administration of endothelin-1 were studied in the anaesthetized cat. Intravitreal injection of 0.4 nmol endothelin-1 induced a 34 +/- 10% (n = 5; P less than 0.05) reduction in retinal blood flow in the experimental eye compared to the control eye 80 minutes after the injection. Blood flow in the ciliary body, iris and choroid remained unaffected by the injection of endothelin-1. Intracameral administration of endothelin-1 at pmol doses caused a reduction in pupil size, an increase in the aqueous humor protein concentration (indicating a break-down of the blood-aqueous barrier) and an increase in the concentration of prostaglandin E2 in the aqueous humor. The effect of endothelin-1 on pupil size was abolished by indomethacin pretreatment, indicating that this effect was mediated by arachidonic acid metabolites.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anterior Chamber / drug effects
  • Aqueous Humor / metabolism
  • Blood Flow Velocity / drug effects
  • Cats
  • Dinoprostone / metabolism
  • Endothelins / pharmacology*
  • Eye / drug effects*
  • Eye / metabolism
  • Eye / physiopathology
  • Eye Proteins / metabolism
  • Female
  • Indomethacin / pharmacology
  • Intraocular Pressure / drug effects
  • Male
  • Pupil / drug effects
  • Retinal Vessels / drug effects


  • Endothelins
  • Eye Proteins
  • Dinoprostone
  • Indomethacin