Prediction of hospital disposition after thrombolysis for acute ischemic stroke using the National Institutes of Health Stroke Scale

Arch Neurol. 2004 Jul;61(7):1061-4. doi: 10.1001/archneur.61.7.1061.


Background: Early determination of discharge destination after acute stroke may promote earlier rehabilitation and reduce costs by shortening the duration of hospitalization.

Objective: To determine whether the National Institutes of Health Stroke Scale (NIHSS) score predicts disposition in stroke patients treated with thrombolysis.

Design: Cohort study.

Setting: Academic and community hospitals from 3 countries.

Patients: Five hundred forty-six patients with acute ischemic stroke treated with recombinant tissue plasminogen activator (rt-PA).

Interventions: Medical records were reviewed for demographic information, vascular risk factors, location of stroke, initial NIHSS score, acute hospital disposition, and complications of symptomatic or asymptomatic intracerebral hemorrhage (ICH).

Main outcome measure: Discharge destination to home, acute rehabilitation, or nursing facility.

Results: In multinomial regression analysis, increasing NIHSS score was a robust and independent predictor of discharge to rehabilitation or nursing facilities, roughly doubling for each 5-point increment. Patients who developed symptomatic ICH were never discharged to home, but asymptomatic ICH had no significant independent effect on disposition.

Conclusions: Stroke severity as determined by the admission NIHSS score is the major independent predictor of disposition after hospitalization and treatment with rt-PA for acute stroke in a broad-based population. However, symptomatic ICH after rt-PA is a catastrophic event that may preclude discharge to home.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Female
  • Hospitalization* / statistics & numerical data
  • Humans
  • Male
  • Middle Aged
  • National Institutes of Health (U.S.)* / statistics & numerical data
  • Patient Discharge* / statistics & numerical data
  • Predictive Value of Tests
  • Prospective Studies
  • Regression Analysis
  • Retrospective Studies
  • Severity of Illness Index
  • Stroke / epidemiology*
  • Stroke Rehabilitation*
  • Thrombolytic Therapy* / statistics & numerical data
  • Treatment Outcome
  • United States