Occurrence of symptom clusters

J Natl Cancer Inst Monogr. 2004:(32):76-8. doi: 10.1093/jncimonographs/lgh008.


Although concurrent symptoms are frequently reported in clinical practice, symptom management research has not reflected this reality. Concurrent, related symptoms, i.e., symptom clusters, are possibly the next generation of work to be done in the area of symptom management. It has been suggested that certain clusters of symptoms may have a synergistic effect on future patient outcomes, and may predict morbidity. The overall goal of this article is to present initial research in the area, along with strategies for development of the concept of symptom clusters. In addition, a working definition of symptom clusters is offered, as well as current issues with the concept and suggestions for future research.

Publication types

  • Review

MeSH terms

  • Comorbidity
  • Depressive Disorder / etiology*
  • Depressive Disorder / pathology
  • Depressive Disorder / therapy
  • Fatigue / etiology*
  • Fatigue / pathology
  • Fatigue / therapy
  • Humans
  • Neoplasms / complications*
  • Pain / etiology*
  • Pain / pathology
  • Pain Management
  • Palliative Care